hi guys   

look i'm having Futaba T6EXAP and it's cable and have aerofly simulator.
first thing, can a tx run as a simulator device on aerofly simulator
secondly, if can run what is the right way to do its setup or configaration.

thank you

Of course a TX can be used in the sim.
Connect your TX to the PC, once it is recognized, open aerofly go to the 'controls' and select your device form the list, then 'calibrate' it, and you are ready to fly!